UMR 7241 - U1050

Mice, Molecules and Synapse formation

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Synapses, molecules, transgenesis, mice, development

ENP label: 

2007

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR 7241 - U1050

Le cerveau est composé de nombreux types de neurones communiquant entre eux via descontacts spécifiques, les synapses. Chaque neurone peut être contacté par plusieurs typesde neurones et à son tour peut envoyer des connections sur différentes autres populationsneuronales : la structure de ces réseaux peut être comparée à celle des réseauxélectriques. Comment la formation de ces réseaux précis est contrôlée reste encore malcompris. Toute perturbation de leur formation peut entraîner des maladies neurodévelopmentales du type autisme.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Center for Interdisciplinary Research in Biology

Initiatives d'Excellence: 

Labex Memolife Idex PSL* ERC Consolidator Grant 2016
Publications

Publications: 

 

Usardi A, Iyer K, Sigoillot SM, Dusonchet A, Selimi F. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Dev Neurobiol. 2017 Jan;77(1):75-92. doi: 10.1002/dneu.22412. Epub 2016 Jul 8. PubMed PMID: 27328461.

Sigoillot SM, Iyer K, Binda F, González-Calvo I, Talleur M, Vodjdani G, Isope P, Selimi F. The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] PubMed PMID: 25660030.

Proville RD, Spolidoro M, Guyon N, Dugué GP, Selimi F, Isope P, Popa D, Léna C. Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements. Nat Neurosci. 2014 Sep;17(9):1233-9. doi: 10.1038/nn.3773. Epub 2014 Jul 27. PubMed PMID: 25064850.

Chaumont J, Guyon N, Valera AM, Dugué GP, Popa D, Marcaggi P, Gautheron V, Reibel-Foisset S, Dieudonné S, Stephan A, Barrot M, Cassel JC, Dupont JL, Doussau F, Poulain B, Selimi F, Léna C, Isope P. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16223-8. doi: 10.1073/pnas.1302310110. Epub 2013 Sep 17. PubMed PMID: 24046366; PubMed Central PMCID: PMC3791757.

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. PubMed PMID: 23628982; PubMed Central PMCID: PMC3730300.

 

Dynamic and Pathophysiology of Neuronal Networks

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Synaptic plasticity
dopamine
Parkinson’s disease
neuronal networks
basal ganglia
GABAergic interneurons
endocannabinoids

ENP label: 

2007

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR 7241 - U1050

 Our research is focused on encoding learning and memory in the basal ganglia, a set of subcortical nuclei implicated in the adaptive control of behavior. Reciprocally connected with the cerebral cortex and the limbic system, the basal ganglia participate to the detection of environmental cues and to the selection of appropriate actions based on motivation and expectancy of reward.

Leader

Leader: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

LabEx MemoLife
Publications

Publications: 

Valtcheva S, Venance L. Astrocytes gate Hebbian synaptic plasticity in the striatum. Nat Commun. 2016 Dec 20;7:13845. doi: 10.1038/ncomms13845. 

Cui Y, Paille V, Xu H, Genet S, Delord B, Fino E, Berry H, Venance L. Endocannabinoids mediate bidirectional striatal spike-timing dependent plasticity. J Physiol. 2015 Apr 15. doi: 10.1113/JP270324.

Paille V#, Fino E#, Du K, Morera-Herreras T##, Perez S#, Hellgren Kotaleski J & Venance L# (2013) GABAergic circuits control spike-timing-dependent plasticity. J Neurosci. 33:9353-9363.

Nelson MJ, Bosch C#, Venance L# & Pouget P (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. J Neurosci. 33(7):2821-7.

Bosch C#, Mailly P, Degos B#, Deniau JM# & Venance L #(2012) Preservation of the hyperdirect pathway of basal ganglia in a rodent brain slice. Neuroscience 215, 31-41.

Evans RC, Morera-Herreras T#, Cui Y#, Du K, Sheehan T, Kotaleski JH, Venance L# & Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol. 8, e1002493.

Puente N, Cui Y#, Lassalle O, Lafourcade M, Georges F, Venance L#*, Grandes P* & Manzoni OJ* (2011) Polymodal activation of the endocannabinoid system in the extended amygdala. Nature Neuroscience 14(12), 1542-7. *: co-senior authors Pandolfo, P, Silveirinha, V, dos Santos-Rodrigues, A, Venance, L#, Ledent, C, Takahashi, RN, Cunha, RA & Köfalvi, A 2011

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum?, Eur J Pharmacol. Vol.655(1-3), pp. 38-45.