U1130 UMR8246 UMCR18
L’objectif général de notre équipe de recherche est de mieux comprendre les mécanismes impliqués dans l’émergence des premiers réseaux synaptiques au cours du développement du système nerveux cetral, en utilisant la moelle épinière embryonnaire comme modèle principal. Nous nous intéressons notamment aux mécanismes sous-tendant l’activité neuronale précoce et au rôle de cette activité dans la synaptogenèse et la mise en place de premiers réseaux synaptiques fonctionnels. Notre équipe s’intéresse également au rôle des interactions entre neurones et cellules gliales dans ces mêmes processus.
To decipher the molecular mechanisms that allow brain gene expression to adapt to environmental challenges, we focus on the function of inducible transcription factors. Glucocorticoid hormones (GC) plays a key role in physiological and psychological responses to stress. It has multifaceted functions in the brain, most likely reflecting distinct actions in different brain areas and cell populations.
We aim at understanding the neural bases of navigation and spatial memory. The principal objective of our work is to provide a comprehensive characterization of how the cerebellum participates to spatial cognition.
This contribution presumably operates, at different levels, including the computation of sensory-motor signals and a functional influence on forebrain areas supporting memory and executive functions (e.g. hippocampus and/or associative cortices).
Our team carries out preclinical studies to better understand psychiatric diseases and to discover innovative therapies. We develop animal models and characterize synaptic targets which play a role in neurotransmission (mostly neurotransmitter transporters). This work is also carried out in humans using genetic and anatomical approaches, specifically focusing on autism and mental retardation.
Dopamine (DA) projections from the midbrain (including ventral tegmental area - VTA and substantia nigra - SN) to striatum and frontal cortex play a major role in behavioral actions controlled by reward and in the formation of habits. The dopaminergic system is also involved in drug addiction.
The main focus of our research is the plasticity and development of human brain tumors
We are interested in understanding how interactions between cell intrinsic and extrinsic signaling pathways control the stem and tumor-initiating properties of glioma stem cells.
Glutamate is the major neurotransmitter of CNS. Before its exocytotic release in the synaptic cleft, glutamate is loaded into synaptic vesicles by three transporters named VGLUT1-3. In the rodent brain, VGLUT1-3 are distributed in three complementary glutamatergic systems showing little overlap. VGLUT1 is essentially cortical, VGLUT2 subcortical and VGLUT3 is present in neurons using other transmitters than glutamate (cholinergic interneurons from the striatum, GABAergic interneurons from the hippocampus and cortex and serotonergic neurons).
The team “Cortical network and Neurovascular Coupling” studies neuronal circuits and their relationships with the glio-vascular network in the cerebral cortex. Our previous work has advanced our knowledge of neocortical neuronal types, of their sensitivity to afferent signals, of their places in the functional architecture of intracortical peptidergic transmission, and of their differential roles in neurovascular coupling.