Sabrina Davis,Jean-Vianney Barnier, Valérie Enderlin, Roseline Poirier, Sandrine Guyon, Véronique Rousseau, Ophélie Vacca, Charlotte Castillon, Mehdi Belmaati, Kevin Duarte, Faouzi Zarrouki

Cellular and molecular mechanisms of plasticity and memory

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Synaptic plasticity
Learning and Memory
Adult hippocampal neurogenesis
Intellectual deficiencies
Alzheimer's disease

ENP label: 

2012

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

Research in the team focuses on the cellular and molecular mechanisms of learning and memory and on identifying mechanisms responsible for memory dysfunction in brain pathologies. Our objective is to identify in different structures of the brain such as the hippocampus and cortex the cellular and molecular mechanisms underlying brain of plasticity, to characterize their role in the formation of memories and identify networks and brain structures within which these changes occur during the laying down of memories.

Leader

Leader: 

Personal

Team members: 

Sabrina Davis,Jean-Vianney Barnier, Valérie Enderlin, Roseline Poirier, Sandrine Guyon, Véronique Rousseau, Ophélie Vacca, Charlotte Castillon, Mehdi Belmaati, Kevin Duarte, Faouzi Zarrouki
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud 11

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Département Cognition & Comportements

Initiatives d'Excellence: 

Idex NeuroSaclay, contrat ANR
Publications

Publications: 

Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Enderlin E. (2014) PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments. Hippocampus, 24(11) : 1381-1393.

Vaillend C, Chaussenot R. (2017) Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. Hum Mol Genet, 26(6):1041-1055.

Maglorius Renkilaraj MR, Baudouin L, Wells CM, Doulazmi M, Wehrlé R, Cannaya V, Bachelin C, Barnier JV, Jia Z, Nait Oumesmar B, Dusart I, Bouslama-Oueghlani L (2017) The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation. Neurobiol Dis ; 98:137-148.

Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H, Davis S (2016) Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer’s Disease. J Alzheimers Dis.51(4):1157-1173.

Goyenvalle A, Griffith G, Babbs A, El Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. (2015) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med. 21(3):270-5.