Pierre-Yves Plaçais

Genes and Dynamics of Memory Systems

Main field of research: 

Neurophysiology / systems neuroscience


olfactory learning
long-term memory
Drosophila mutants
neuronal networks
Alzheimer's disease
Brain imaging
energy metabolism

ENP label: 


Research Center / Institute: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Research Unit Code: 






Team members: 

Valérie Goguel
Pierre-Yves Plaçais
Alice Pavlowsky
Laure Pasquer
Lisa Scheunemann
Eloïse de Tredern
Julia Minatchy
Johann Schor
Olivier Mantha

Principal Institution: 


Affiliated institutions: 



Laboratoire Plasticité du Cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL, EMBO


Dolan, M.-J., Belliart-Guérin, G., Bates, A.S., Frechter, S. , Lampin-Saint-Amaux, A. , Aso, Y. , Roberts, R.J.V. , Schlegel, P., Wong, A., , Hammad, A. , Bock, D., Rubin, G.M., Preat, T., Plaçais, P.-Y.* and Jefferis, G.S.X.E.* (2018). Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila. Neuron, 100: 1-18.

Pavlowsky, A., Schor , J., Plaçais, P.-Y., and Preat, T. (2018). A GABAergic feedback shapes dopaminergic input  on the Drosophila mushroom body  to promote appetitive long-term memory. Curr Biol, 28: 1–11.

Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M., and Preat, T. (2018). Dunce phosphodiesterase acts as a checkpoint for Drosophila long-term memory in a pair of serotonergic neurons. Neuron, 98:350-365.

Turrel, O., Goguel, V.* and Preat, T.* (2017). Drosophila neprilysin 1 rescues memory deficits caused by amyloid-β peptide. J Neurosci, 37(43):10334-10345.

Plaçais, P.-Y., de Tredern, E., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., and Preat, T. (2017). Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. Nat Commun, 8:15510.

Musso, P.-Y., Tchenio, P.* and Preat, T.* (2015). Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila. Cell Rep, 10: 1-9.

Plaçais, P.-Y. and Preat, T. (2013). To favor survival under food shortage, the brain disables costly memory. Science, 339(6118): 440-442.

Plaçais, P.-Y., Trannoy, S., Isabel, G., Aso, Y., Siwanowicz, I., Belliart-Guérin, G., Vernier, P., Birman, S., Tanimoto, H. and Preat, T. (2012). Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nat Neurosci, 15(4): 592-599.

Séjourné, J., Plaçais, P.-Y., Aso, Y., Siwanowicz, I., Trannoy, S., Vladimiros, T., Tedjakumala, S.R., Rubin, G.M., Tchénio, P., Ito, K., Isabel, G., Tanimoto, H.* and Preat, T.* (2011). Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci, 14(7): 903-910.