Mr
Bruno GASNIER
Research Director
Chercheur
ED 419 ED 436
11-03-2015
15-01-2014
13-03-2015
Available to host a PhD student
Cellular pathology of neuronal ceroid lipofuscinoses

Team

Bruno GASNIER
RESEARCH INTERESTS: The nervous system is highly compartmentalized at diverse levels. At molecular level, this compartmentalization involves the sequestration and clearance of metabolites and...

Biography/CV

CURRENT SITUATION

CNRS Research Director

Group Leader at CNRS/Paris Descartes UMR 8192, 45 rue des Saints-Pères, 75006 Paris

Jan. 14: Deputy Director of CNRS/Paris Descartes UMR ?Neurophotonics? with V. Emiliani

 

EDUCATION

1980- 1985 Ecole Normale Supérieure, Paris

1985 PhD in Cellular and Molecular Pharmacology; Paris 6 University

 

PROFESSIONAL EXPERIENCE

1986-1987 Postdoc at the Gulbenkian Institute of Science, Oeiras, Portugal

1988-2001 CNRS scientist

1994-2010 Group leader at the Institut de Biologie Physico-Chimique

2002- CNRS research director

2005-2008 Head of the CNRS research unit UPR 1929

2009-2013 Group leader at CNRS/Paris Descartes ?Membrane dynamics? unit (UMR 8192)

2014- Deputy Director with V. Emiliani of CNRS/Paris Descartes ?Neurophotonics? unit

 

PUBLICATIONS AND PATENTS

51 publications in journals with review committee, 3 book chapters, 1 patent

Number of citations: 2517

h-index : 28

 

5 SELECTED PUBLICATIONS

Sagné C., El Mestikawy S., Isambert M.F., Hamon M., Henry J.P., Giros B. & Gasnier B. (1997) Cloning of a functional vesicular

GABA and glycine transporter by screening of genome databases. FEBS Letters 417, 177-183

Morin, P., Sagné, C. & Gasnier, B. (2004) Functional characterization of wild-type and mutant human sialin. EMBO Journal 23,

4560-4570

Aubrey, K.R., Rossi, F.M., Ruivo, R., Alboni, S., Bellenchi, G.C., Le Goff, A., Gasnier*, B. Supplisson*, S. (2007) The transporters

GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. J. Neurosci. 27, 6273-6281. (*co-senior authors)

Ruivo R., Bellenchi G.C., Chen X., Zifarelli G., Sagné C., Debacker C., Pusch M., Supplisson S., Gasnier B. (2012) Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Proc. Natl. Acad. Sci. USA 109, E210-E217.

Jézégou, A., Llinares, E., Anne, C., Kieffer-Jaquinod, S., O?Regan, S., Aupetit, J., Chabli, A., Sagné, C., Debacker, C.,

Chadefaux-Vekemans, B., Journet, A., André, B., Gasnier, B. (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid

exporter underlying the action of cysteamine in cystinosis therapy. Proc. Natl. Acad. Sci. USA 109, E3434?E3443

 

INVITED ORAL PRESENTATIONS

24 invited talks in international meetings

33 invited seminars in Europe, USA, India and China

 

5 SELECTED INVITED CONFERENCES

12th International Congress on Neuronal Ceroid Lipofuscinoses, Hamburg, Germany 3-6/6/2009

Gordon Research Conference on Lysosomal Diseases, Galveston TX, USA 23-28/1/2011; session chair

Satellite meeting ?Vesicular transporters? of the 8th FENS Forum of Neurosciences, Barcelona, Spain 13/7/2012

10th National Neuronal Ceroid Lipofuscinosis (NCL) Foundation Congress, Hamburg, Germany, 3/12/2012

Gordon Research Conference on Mechanisms of Membrane Transport, Mount Holyoke College, South Hadley MA, 16-21/6/2013

19th European Study Group on Lysosomal Diseases Workshop, Leibnitz, Austria, 25-29/9/2013

RECENT GRANTS

ANR (2005-7, coordinator; 2009-11, partner); Batten Disease Support & Research Association (BDSRA) USA (2011, PI); Cystinosis

Research Foundation USA (2007-9, coordinator; 2010-12, coordinator; 2012-14, coordinator); Fédération pour la Recherche sur le

Cerveau (2008, partner); Fondation Louis D (2010, partner); Paris Descartes in-house interdisciplinary grants (2011, coordinator);

Vaincre les Maladies Lysosomales (2010, PI; 2013, PI)

 

COLLECTIVE RESPONSIBILITIES

Teaching in several Neuroscience Masters (~20 h/year at Paris Descartes; Paris Curie; and Paris Sud)

Supervision of 7 PhD thesis; Reviewer/examinator of 21 theses

Grant review for NSF, BBSRC, FNRS Belgium, HRB Ireland, Czech Science Foundation, etc

 

MEMBERSHIPS

ASBMB ; Biophysical Society ; Société des Neurosciences

Scientific advisory board of ?Vaincre les Maladies Lysosomales?