Research Highlight: Hippocampo-cortical coupling mediates memory consolidation during sleep
Memory consolidation is thought to be mediated by a dialog between the hippocampus and the neortex during sleep, but direct experimental evidence has remained elusive. ENP leader Michaël Zugaro and coll. now report for the first time that temporary memory traces can be consolidated in rats by boosting the functional oscillatory coupling between hippocampal sharp wave-ripples, cortical delta waves and thalamo-cortical spindles during sleep. The authors show that hippocampo-cortical coupling selectively results in reorganization of medial prefrontal cortical subnetworks that parallel memory consolidation and recall improvements in a spatial memory task.
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Hippocampo-cortical coupling mediates memory consolidation during sleep.Maingret N, Girardeau G, Todorova R, Goutierre M, *Zugaro M*.Nat Neurosci. 2016 Jul;19(7):959-64. doi: 10.1038/nn.4304.