Mechanisms of activation and attraction of microglial cells by motorneurons in mouse models of amyotrophic lateral sclerosis.
ENP alumna Ana Barbeito studied microglia and their recruitment during normal development and in neurodegenerative diseases. In her Journal of Neural Transmission article, she discusses the role of microglia in amyotrophic lateral sclerosis. She points out that microglia activation increases as the disease progresses and that microglia are also linked to toxic and neurotrophic factors. Check out the article for more information:
Barbeito AG, Mesci P, Boillée S. Motor neuron-immune interactions: the vicious circle of ALS. J Neural Transmission. August 2010. 117(8): 981-1000.
Key words: Neuroinflammation ALS Microglia Neurodegeneration T lymphocytes Macrophages Cytokines
Figure 1B from Barbeito, Mesci and Boillée. J Neural Transmission. 2010. Illustration of how immune cells influence motor neuron survival in ALS.