September 2007
29 September 2011

Years 2-4

October 1, 2008 - September 29, 2011
ED 158
Université Pierre et Marie Curie

Role of Semaphorin6A and its receptors PlexinA2 in the development of the retina

The thesis abstract is available here


Recruited as PostDoc at University of Minnesota, Minneapolis.

Year 1


Aijaz Parray, an alumnus of the ENP graduate program, contributed to an important finding on the organization of the retina. He and his teammates used a mouse model to study stratification of the layers of the retina. They discovered that the transmembrane semaphorin Sema6A targets its receptor PlexA4 to control lamina-specific neuronal stratification. For more details, see the article:

Matsuoka RL, Nguygen-Ba-Charvet KT, Parray A, Badea TC, Chédotal A, Kolodkin AL. Transmembrane semaphorin signaling controls laminar stratification in the mammalian retina. Nature. 2011. 470: 259-263. 

Figure 1a and b from Matsuoka et al., Nature, 2011. Immunostained sections of adult retina in wild-type and PlexinA4 null mice. Immunohistochemistry conducted against tyrosine hydroxylase in these images


Nervous systems are composed of a network of synaptic connections among excitable cells. This network develops as axons extend from presynaptic neurons and grow often long distances to reach their...